Publications
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2024
59. H.Chen, D. Wu, J. Holzinger, R. Götz, D. Didier, A.K. Schütz, S. Schneider, P. Kielkowski. Aryl radicals generated from aryl pinacol boronates modify peptides and proteins. Eur. J. O. C., 2024, accepted for publication
58. Chen, S.A., Fiedler, M.K., Gronauer, T.F., Omelkob, O., von Wrisberg, M.-K., Wang, T., Schneider, S., Sieber, S.A., Zacharias, M. Unraveling the mechanism of small molecule induced activation of Staphylococcus aureus signal peptidase IB. Comms. Biol. 2024, 7, 895. doi: 10.1038/s42003-024-06575-x
57. Tölke A.J., Gaisbauer J.F., Gärtner Y.V., Steigenberger B., Holovan A., Streshnev F., Schneider S., Müller M., Carell T. Efficient tandem Cu-catalyzed Click synthesis of multi-sugar-modified oligonucleotides. Angew. Chem. Int. Ed. Engl. 2024, e202405161. doi: 10.1002/anie.202405161.
56. Wu, D, Koscic, A., Schneider, S., Dubini, R. C. A., Rodriguez C. D., Schneider, S., Rovó, P. "Unveiling the dynamic self-assembly of a recombinant dragline-silk mimicking protein", Biomolecules, doi: 10.1021/acs.biomac.3c01239
55. Phi, M.T., Singer, H. Zäh, F., Haisch, C., Schneider, S., Op den Camp, H., Daumann, L. J. "Assessing Lanthanide-Dependent Methanol Dehydrogenase Activity: The Assay Matters." ChemBioChem, e202300811.doi: 10.1002/cbic.202300811
2022
54. Ranava, D., Scheidler, C. M., Pfanzelt, M., Sieber, S. A.*, Schneider, S.*, Yap, M.-N. F. "Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein." PNAS, 2022, doi: 10.1073/pnas.2207257119 *corresponding author
53. F. R. Traube, M. Stern, A. J. Tölke, M. Rudelius, E. Mejías-Pérez, N. Raddaoui, B. M. Kümmerer, C. Douat, F. Streshnev, M. Albanese, P. R. Wratil, Y. V. Gärtner, M. Nainytė, G. Giorgio, S. Michalakis, S. Schneider, H. Streeck, M. Müller, O. T. Keppler, T. Carell "Suppression of SARS-CoV-2 replication with stabilized and click-chemistry modified siRNAs." Angew. Chem. Int. Ed., 2022, e202204556, doi: 10.1002/ange.202204556
52. Makarova, D., Teleka, A., Beckera, T., von Wrisberg, M.-K., Schneider, S., Kielkowski, P. Clickable report tags for identification of modified peptides by mass spectrometry. J. Mass Spectr. doi: 10.1002/jms.4812
51. Schmidl, D. Jonasson, N.S.W., Menke, A., Schneider, S., Daumann, L. Spectroscopic and in vitro investigations of Fe2+/α-Ketoglutarate-dependent enzymes involved in nucleic acid repair and modification.
ChemBioChem doi: 10.1002/cbic.202100605 PDF
50. Kick, L.M., von Wrisberg, M.-K., Runtsch, L. S., Schneider, S. Structure and mechanism of the RNA dependent RNase Cas13a from Rhodobacter capsulatus. Com. Biol. doi: 10.1038/s42003-022-03025-4 PDF
(BioRXiv https://www.biorxiv.org/content/10.1101/2021.06.07.447304v1)
2021
49. Aldemir, H. Shu. S., Schaefers, F., Hong, H., Richarz, R. Harteis, S., Einsiedler, M., Milzarek, T.M., Schneider, S.*, Gulder, T.A.M.* Carrier protein-free enzymatic biaryl coupling in arylomycin A2 assembly and structure of the cytochrome P450 AryC. Chem. Eur. J., 28:e202104451. doi: 10.1002/chem.202104451. *corresponding author
48. Cornelia A. Karg,C.A., Wang,S., Danaf, N., Pemberton, R., Bernard, D., Kretschmer, M., Schneider, S., Zisis, T., Vollmar, A.M., Lamb, D.C., Zahler, S., Moser, S. Tetrapyrrolic pigments are actin-targeting compounds. Angew. Chem. Int. Ed., 2021, https://doi.org/10.1002/anie.202107813
47. Du, J., von Wrisberg, M.-K., Gulen, B., Stahl, M., Pett, C., Hedberg, C., Lang, K.*, Schneider, S.*, Itzen, A.* Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1. Nat. Com. 2021, 12(1), p. 460. doi: 10.1038/s41467-020-20702-2.
*corresponding author
2020
46. Hübner, I., Dienemann, J-N., Friederich, J., Schneider, S., Sieber, S. A. Tailored cofactor traps for the in situ detection of hemithioacetal-forming pyridoxal kinases. ACS Chem. Biol. 2020, 15(12), p. 3227-3234. doi: 10.1021/acschembio.0c00787.
45. Pinheiro, B., Scheidler, C., Kielkowski, P., Schmid, M., Forné, I., Ye, S., Takano, E., Imhof, A., Sieber, S., Schneider, S.*, Jung, K.* Structure and function of a novel elongation factor P subfamily in Actinobacteria. Cell Rep. 2020, 30, p. 4332-4342.e5. doi: 10.1016/j.celrep.2020.03.009 *corresponding author
44. Scheidler, C. Vrabel, M., Schneider, S. Genetic code expansion, protein expression and protein functionalisation in Bacillus subtilis. ACS Synthetic Biol. 2020, 9, p. 486-493. doi: 10.1021/acssynbio.9b00458
2019
43. Wagner, A., Hofmeister, O., Rolland, S.G., Maiser, A., Aasumets, K., Schmitt, S., Schorpp, K., Feuchtinger, A., Hadian, K., Schneider, S., Zischka, H., Leonhardt, H., Conradt, B., Gerhold, .JM., Wolf, A. Mitochondrial Alkbh1 localises to mtRNA granules and its knockdown induces mitochondrial UPR in humans and C. elegans. J. Cell. Sci., 2019, doi: 10.1242/jcs.223891
42. Wang, S., Gegenfurtner, F., Crevenna, A., Ziegenhain, C., Kliesmete, Z., Enard, W., Mueller, R., Vollmar, A., Schneider, S.*, Zahler, S.* Chivosazole A modulates protein-protein-interactions of actin. J. Nat. Prod. 2019, 82, p. 1961-70. doi: 10.1021/acs.jnatprod.9b00335 *corresponding author
41. Scheidler, C., Kick, L., Schneider, S. Ribosomal peptides and small proteins on the rise. ChemBioChem. 2019, 20, p. 1479-86. doi: 10.1002/cbic.201800715
2018
40. Hoegl, A., Nodwell, M.B., Kirsch, V.C., Bach, N.C., Pfanzelt, M., Stahl, M., Schneider, S., Sieber, S.A. Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics. Nat. Chem. 2018, 10, p. 1234-45, doi: 10.1038/s41557-018-0144-2
39. Stahl M., Korotkov V., Balogh D., Kick L., Gersch M., Pahl A., Kielkowski P., Richter K., Schneider S.*, Sieber S.A.* Selective activation of human caseinolytic protease P (ClpP). Angew. Chem. Int. Ed., 2018, 57, p. 14602-7, doi: 10.1002/anie.201808189. *corresponding author
2017
38. Kläger, S., Heinzlmeir, S., Wilhelm, M., Helm, D. Qiao, H., Polzer, H., Vick, B., Reiter, K., Reinecke, M., Ruprecht, B., Petzoldt, S., Koch, H., Schoof, M., Canevari, G., Casale, E., Re Depaolini, S., Feuchtinger, A., Meng, C., Wu, Z., Zecha, J., Schmidt, T., Rückert., L, Becker, W., Hünges, J., Gohlke, B., Garz, A., König, P., Hahne, H., Ruland, J., Preissner, R., Götze, K., Kayser, G., Tönisson, N., Greif, P., Schlegl, J., Ehrlich, H., Aiche, S., Felder, E., Kramer, K., Schneider, S., Walch, A., Médard, G,. Jeremias, I., Spiekermann, K., Küster, B. The target landscape of clinical kinase drugs. Science, 2017, 358, eaan4368
37. Kick, L., Harteis, S., Koch, M. F., Schneider, S. Mechanistic insights into cyclic peptide generation by DnaE split-inteins through quantitative and structural investigation. ChemBioChem, 2017, http://dx.doi.org/10.1002/cbic.201700503
36. Kirchner, M., Schorpp, K., Hadian, K., Schneider, S. An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system. Sci. Rep., 2017, 7: 7732; doi:10.1038/s41598-017-07870-w
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35. Ebert, C., Simon, N., Schneider, S.*, Carell, T. Structural insights into the recognition of N²-aryl- and C8-aryl DNA lesions by the repair protein XPA/Rad14. ChemBioChem, 2017, doi: 10.1002/cbic.201700169, *corresponding author
34. Kick, L., Kirchner, M., Schneider, S. CRISPR-Cas9: from a bacterial immune system to genome-edited human cells in clinical trials, Bioengineered, 2017, doi: 10.1080/21655979.2017.1299834.
33. Kirchner M., Schneider, S. Gene expression control by Bacillus anthracis purine riboswitches. RNA, 2017, 23, p. 762-9. doi: 10.1261/rna.058792.116.
32. Willkomm S., Oellig, C. A., Zander, A., Restle, T., Keegan, R., Grohmann, D., Schneider, S. Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein. Nat. Microbiol., 2017, doi: 10.1038/nmicrobiol.2017.35
31. Zander, A., Willkomm, S., Ofer, S., van Wolferen, M., Egert, L., Buchmeier, S., Stöckl, S., Tinnefeld, P., Schneider, S., Klingl, A., Albers, S., Werner, F., Grohmann, D. Guide-independent DNA cleavage by archaeal Argonaute from Methanocaldococcus jannaschii. Nat. Microbiol., 2017, doi: 10.1038/nmicrobiol.2017.34
2016
30. Mandl, F. A., Kirsch, V. C. Ugur, I., Kunold, E., Vomacka, J., Fetzer, C., Schneider, S., Richter, K., Fuchs, T. M., Antes, I., Sieber, S. A. Natural product inspired amino-epoxybenzoquinones kill members of the gram-negative pathogen Salmonella by attenuating cellular stress response. Angew. Chem. Int. Ed., 2016, 55, p. 14852-7.
29. Groß, C., Mishra, R., Schneider, K., Médard, G., Wettmarshausen, J., Dittlein, D., Shi, H., Gorka, O., König, P.-A., Fromm, S., Magnanil, G., Ćiković, T., Hartjes, L., Smollich, J., Robertson, A., Cooper, M., Schmidt-Supprian, M., Schuster, M., Schroder, K., Broz, P., Traidl-Hoffmann, C., Beutler, B., Kuster, B., Ruland, J., Schneider, S., Perocchi, F., Groß, O. K+ Efflux-Independent NLRP3 Inflammasome Activation by a Small Molecule Targeting Mitochondria. Immunity, 2016, 45, p. 761-73.
28. Simon, N., Ebert, C., Schneider, S.
Structural basis for bulky adduct DNA lesion recognition by the nucleotide excision repair protein Rad14. Chem. Eur. J., 2016, 22, p. 10782-5.
2015
27. Koch, M., Harteis, S, Blank, I. D., Pestel, G., Tietze, L. F., Ochsenfeld, C., Schneider, S.,* Sieber, S. A.* Structural, biochemical and computational studies reveal the mechanism of selective Aldehyde dehydrogenase 1A1 inhibition by cytotoxic duocarmycin analogs. Angew. Chem. Int. Ed., 2015, 54, p. 13550-4 , *corresponding author
26. Kirchner, M., Schneider, S. CRISPR - Cas: From the bacterial adaptive immune system to a versatile genome engineering toolbox. Angew. Chem. Int. Ed., 2015, 54, p. 13508-14
25. Koch, S. C., Kuper, J., Gasteiger, K. L., Simon, N., Strasser, R., Eisen, D., Geiger, S., Schneider, S., Kisker, C., Carell, T. Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA). Proc. Nat. Acad. Sci., 2015, 112, p. 8272-7
2014
24. Sadeghian, K., Flaig, D., Blank, I. D., Schneider, S., Strasser, R., Stathis, D., Winnacker, M., Carell, T., Ochsenfeld, C. Ribose-activated DNA base-excision repair. Angew. Chem. Int. Ed., 2014, 53, p. 10044-8
23. Harteis, S., Schneider, S. Making the bend: DNA tertiary structure and protein-DNA Interactions. Int. J. Mol. Sci., 2014, 15, p. 12335-63; doi:10.3390/ijms150712335.
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22. Flügel, V., Vrabel, M., Schneider,. S. Structural basis for the site-specific incorporation of lysine derivatives into proteins. PLOS One, 2014, DOI 10.1371/journal.pone.0096198.
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21. Nodwell, M., Koch, M., Alte, F., Schneider, S.*, Sieber, S. A.* A sub-family of ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage. J. Am. Chem. Soc., 2014, 136, p. 4992-9. *corresponding author
2013
20. Schneider, S.*, Gattner, M. J., Vrabel, M., Flügel, V., López-Carrillo, V., Prill, S., Carell, T.* Structural insights into incorporation of norbornene amino acids for click modification of proteins. ChemBioChem, 2013, 14, p. 2114-8. *corresponding author
19. Gehrke, T.*, Lischke, U.*, Gasteiger, K.*, Schneider, S.*, Arnold, S., Müller, H., Stephenson, D., Zipse, H., Carell, T. Unexpected non-Hoogsteen–based mutagenicity mechanism of FaPy-DNA lesions. Nat. Chem. Biol., 2013, 9, p. 455-61 . *These authors contributed equally
2012
18. Gopalakrishnan, R., Kozany, C., Wang, Y., Schneider, S., Hoogeland, B., Bracher, A., Hausch, F. Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52. J. Med. Chem., 2012, 55, p. 4123-31.
2011
17. Kaul, C., Müller, M., Wagner, M., Schneider, S., Carell, T. Reversible bond formation enables replication and amplification of a crosslinking salen complex as an orthogonal base pair. Nat. Chem., 2011, 3, p. 794-800.
16. Heil K., Kneuttinger, A. C., Schneider, S., Lischke U., Carell, T. Crystal structures and repair studies reveal the identity and the base-pairing properties of the UV-induced spore photoproduct DNA lesion. Chem. Eur. J, 2011, 17, p. 9651-9657.
2010
15. Schorr, S., Schneider, S., Lammens, K., Hopfner, K.-P., Carell, T. Mechanism of replication blocking and bypass of Y-family polymerase by bulky acetylaminofluorene DNA adducts. Proc. Nat. Acad. Sci., 2010, 107, p. 20720-5.
14. Schneider, S., Reissner, T., Ziv, O., Livneh, Z., Carell, T. Translesion synthesis of 1,3-GTG cisplatin DNA lesions. Chembiochem., 2010, 11, p. 1521-4.
13. Reissner, T.*, Schneider, S.*, Schorr, S., Carell, T. Crystal structure of a cisplatin-1,3-GTG cross-link inside DNA polymerase eta. Angew. Chem. Int. Ed., 2010, 49, p. 3077-80. * These authors contributed equally
12. Glas, A. F., Kaya, E., Schneider, S., Heil, K., Fazio, D., Maul, M. J., Carell, T. DNA (6-4) photolyases reduce dewar isomers for isomerizations into (6-4) lesions. J. Am. Chem. Soc., 2010, 132, p. 3254-5.
2009
11. Glas, A. F., Schneider, S., Maul, M. J., Hennecke U., Carell, T. Crystal structure of the T(6-4)C lesion in complex with a (6-4) DNA photolyase and repair of UV-induced (6-4) and dewar photolesions. Chem. Eur. J, 2009, 15, p. 10387-96.
10. Glas, A. F., Maul, M. J., Cryle, M., Barends, T. R. M., Schneider, S., Kaya, E., Schlichting, I., Carell, T. The archaeal cofactor Fo is a light harvesting antenna chromophor in eukaryotes. Proc. Nat. Acad. Sci., 2009, 106, p. 11540-5.
9. Schneider, S.*, Schorr, S., Carell, T. Crystal structure analysis of DNA lesion repair and tolerance mechanisms. Curr. Oppin. Struct. Biol., 2009, 19, p. 87-95. *corresponding author
2008
8. Maul M. J., Barends T. R., Glas A. F., Cryle M. J., Domratcheva T., Schneider S., Schlichting I., Carell T. Crystal structure and mechanism of a DNA (6-4) photolyase. Angew. Chem. Int. Ed., 2008, 47, p. 10076-80.
7. Schneider, S., Zhang W., Soultanas, P., Paoli, M. Structure of the N-terminal oligomerisation domain of DnaD reveals a unique tetramerisation motif and provides insights into scaffold formation and DNA remodelling. J. Mol. Biol., 2008, 24, p. 1237-50.
2007
6. Schneider, S., Marles-Wright, J., Sharp, K. H., Paoli, M. Diversity and conservation of interactions for binding heme. Nat. Prod. Rep., 2007, 24, p. 621-30.
5. Sharp, K. H., Schneider, S., Cockayne, A., Paoli, M. Crystal structure of the heme-IsdC complex, the central conduit of the Isd iron/heme uptake system in Staphylococcus aureus. J. Biol. Chem., 2007, 282, p. 10625-31.
4. Schneider, S., Carneiro, M. J. V. M., Ioannou, C., Soultanas, P., Paoli, M. Crystallization and X-ray diffraction analysis of the DNA remodelling protein DnaD from Bacillus subtilis. Acta Cryst. F, 2007, 63, p. 110-3.
2006
3. Schneider, S., Sharp, K. H., Barker, P. D., Paoli, M. An induced-fit conformational change underlies the binding mechanism of the heme transport proteobacteria-protein HemS. J. Biol. Chem., 2006, 281, p. 32606-10.
2005
2. Schneider, S., Paoli, M. Crystallization and preliminary X-ray diraction analysis of the haem- binding protein HemS from Yersinia enterocolitica. Acta Cryst. F, 2005, 61, p. 802-5.
1. Grimm, T., Schneider, S., Naschberger, L., Huber, J., Guenzi, E., Kieser, A., Reitmeir, P., Schulz, T. F., Morris, C. A., Stürzl, M. EBV latent membrane protein-1 protects B-cells from apoptosis by inhibition of Bax. Blood, 2005, 105, p. 3263-9.
Bookchapters
1. Schneider, S. CRISPR-Cas9: Revolution der Biologie durch ein bakterielles Immunsystem. Unendliche Weiten - Kreuz und quer durchs Chemie-Universum // GDCh-Jubiläumsbuch, 2016
Other
5. Schneider, S. CRISPR-Cas9 in der Anwendung - wo stehen wir heute? Trendberichte Biochemie - Nachrichten aus der Chemie, 2020
4. Schneider, S. DNA und RNA - mehr als nur Träger der genetischen Information. BIOspektrum, 2018, 0.4.18
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3. Schneider, S. Genommodifikation in der eigenen Küche. BIOspektrum, 2017, 05.17, p. 601
2. Schneider, S. Genommodifikation und Genregulation leicht gemacht: Bakterielle Immunsysteme und ihre Anwendung als Werkzeuge für Forschung und Medizin. Trendberichte Biochemie - Nachrichten aus der Chemie, 2016
1. Schneider, S. CRISPR-Cas: universelles Werkzeug für die Gentechnik. Trendberichte Biochemie - Nachrichten aus der Chemie, 2015